Islands in the Stream |
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Mara Steinkamp, Graduate Student, Human Genetics and Diane Robins, Ph.D., Professor,
Department of Human Genetics
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| The prostate contains many secretory ducts, each surrounded by a single layer of epithelial cells. Shown here are normal prostate glands from a mouse with proliferating nuclei stained deep red. With age, these epithelial cells can loose their normal growth control and mound up, in a formation known as prostatic intraepithelial neoplasia (PIN). We can use a marker of cell division to monitor PIN, which is a precursor to prostate cancer. In this mouse model we can study the genetic and hormonal factors that control the progression from PIN to an actual tumor. |
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