Out of Control

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Dweepanita Das, Ph.D., Postdoctoral Fellow, Human Genetics and Diane Robins, Ph.D., Professor, Department of Human Genetics
The prostate contains many secretory ducts, each surrounded by a single layer of epithelial cells. With age, these epithelial cells can loose their normal growth control and mound up, in a formation known as prostatic intraepithelial neoplasia (PIN). Shown here are prostate glands from a mouse model of PIN. Normal cell nuclei are stained lavender, and abnormally proliferating nuclei are stained brown. Continued growth of these cells will lead to prostate cancer. In this mouse model, we can study the genetic and hormonal factors that control the progression from PIN to an actual tumor.
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